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Simplified

“You never change things by fighting against the existing reality. To change something, build a new model that makes the old model obsolete.”

Buckminster Fuller

Today’s genomic sequencing labs are processing millions of biological samples every year using methods that have barely changed over decades, creating bottlenecks that stifle cost effective, efficient workflow. The traditional approach to solving this is through automation and incremental improvements to current processes.

CURRENT CHALLENGES

Time Consuming

Current isolation, purification and sample preparation methods using beads and columns can take up to several days to complete.

Expensive

The labor involved with sample preparation has become a major component of overall NGS costs.

Error Prone

Current sample preparation assays involve many complex steps – each of which can contribute to errors in the final data.

Specialized Training Required

The complexity of traditional sample processing requires specially trained lab technicians, limiting the use of NGS to specialized labs.

SIMPLSEQ’S PROPRIETARY SOLUTION

REDUCED HANDS ON TIME LOWER COSTS

By eliminating many steps needed in current processing, lab technicians are more efficient, driving down labor costs.

FEWER STEPS INCREASES THROUGHPUT

Sequencing turnaround times can be greatly improved with our simplified process.

GREATER ACCURACY

With steps eliminated our sample prep reduces the chances of errors in the final data.

NO Specialized Training Required

Our process can be performed by general lab technicians which will allow more NGS sequencing at patient point of care.

The choice is Simpl – more information faster at a lower cost.

BREAKTHROUGH

A key advantage of our proprietary process is that the original isolated nucleic acids remain bound to a solid support and can be reused for multiple reactions. This will allow labs to “biobank” the original DNA or RNA for future testing for the first time ever.

TECHNOLOGY

Traditional nucleic acid extraction, isolation and purification procedures are labor intensive, require multiple pieces of laboratory equipment and are not specific for nucleic acids. The standard practice utilizes ionic charge as a means for interaction of nucleic acids to either microsphere beads or filters in spin columns. This interaction is not specific for nucleic acids, the location or orientation of the nucleic acid molecules.

Our solution provides for nucleic acid specific binding in a single 3’ orientation. These properties allow for direct affinity or covalent binding which allows the nucleic acid molecule to be used directly in multiple molecular biology applications, such as cDNA synthesis, primer extension, regeneration of original input material and PCR based methodologies.

Assays performed on the bound nucleic acid molecules will produce materials suitable for PCR and NGS based analysis. With SimplSeq’s process, NGS assays will not require ligation, multiple PCR stages or complicated targeted capture hybridization steps.

The completed NGS library will be processed in fewer steps, with far less manipulation providing a more robust system without the traditional methods that contribute to known errors and shortcomings in the standard NGS sample preparation assays.

The Team

Our core management team is highly experienced in lab operations, molecular science, business operations and finance. They are supported by a strong advisory board of over two dozen industry professionals.

Jay Goth

Jay Goth has operated as a C-level executive, investment banker, fund manager and consultant for a variety of industries. He serves on the board of directors for several for-profit and non-profit organizations and was recognized as the SBA’s Small Business Champion of the Year in 2016.

Brandon Young

Brandon Young has spent over 20 years utilizing technology to improve testing and detection of genetic variation in human diseases. He has extensive experience in research, set-up, operations, configuration and P&L of running genomics labs and has provided data and analysis for multiple national and international clinical trials.

John Powers

John Powers spent 22 years in the wireless industry driving acceptance and adoption of new technologies. He followed this with several C-level executive positions in the precision medicine space and has a strong background in operations and engineering.

Dr. John Spinosa

John Spinosa, M.D., Ph.D., has held numerous medical staff leadership positions including Chief of Staff and Department Chair of Pathology. He has held industry positions with private and public companies and is associated with several professional organizations.

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